Viral

Many viral ORFs encode a homolog to the cellular BCL-2 protein, as a result of horizontal (and also possibly lateral) gene transfer events. Several subclasses of viral BCL-2 homologs could be defined (representative proteins are listed below).

Adenoviridae

Gene name	Protein name	Synonyms	Primary function	BCL2DB acc.	Reference
E1B19K	E1B 19K	E1Bs	inhibitor	P03246	Chiou et al., 1994

Asfarviridae

Gene name	Protein name	Synonyms	Primary function	BCL2DB acc.	Reference
LMW5-HL	LMW5-HL	A179L	inhibitor	Q07819	Neilan et al., 1993

Herpesviridae

Gene name	Protein name	Synonyms	Primary function	BCL2DB acc.	Reference
A9	A9	-	inhibitor	O36423	Ensser et al., 1997
BALF1	BALF1	-	inhibitor	P0CK58	Marshall et al., 1999
BHRF1	BHRF1	-	inhibitor	P03182	Pfitzner et al., 1987
V-BCL-2	v-Bcl-2	BoHV4	inhibitor	Q9WH78	Bellows et al., 2000
M11	M11	gammaHV68 Bcl-2	inhibitor	P89884	Virgin et al., 1997
ORF16	ORF16	KsBcl-2	inhibitor	Q76RI8	Cheng et al., 1997
vNR13	vNR13	-	inhibitor	Q9DH00	Aouacheria et al., 2003

Iridoviridae

Gene name	Protein name	Synonyms	Primary function	BCL2DB acc.	Reference
070L	070L	-	uncharacterized	Q677S5	Zhang et al., 2004
097R	097R	-	uncharacterized	Q6GZM8	Tan et al., 2004
ORF115R	ORF115R	-	uncharacterized	Q5YFF0	Song et al., 2004

Poxviridae

Gene name	Protein name	Synonyms	Primary function	BCL2DB acc.	Reference
FPV039	FPV039	-	inhibitor	Q9J5G4	Afonso et al., 2000
ORFV125	ORFV125	-	inhibitor	Q80G30	Westphal et al., 2007