Cellular
The repertoire of cellular BCL-2 family proteins contains several groups of paralogs. Below are listed the well-annotated groups. All data listed in the tables refers to human proteins unless otherwise noted.
BCL-2-like
Gene name | Protein name | Synonyms | Primary function | BCL2DB acc. | Reference |
---|---|---|---|---|---|
BCL-2 | Bcl-2 | - | inhibitor | P10415 | Tsujimoto et al.,1984 |
BCL2L1 | Bcl-xL | Bcl2l1 | inhibitor | Q07817 | Boise et al., 1993 |
BCL2L2 | Bcl-w | Bcl2l2 | inhibitor | Q92843 | Gibson et al., 1996 |
MCL-1 | Mcl-1 | Bcl2l3 | inhibitor | Q07820 | Kozopas et al., 1993 |
BCL2L10 | Bcl2l10 | Bcl-B, Nrh, Nr-13, Diva, Boo | inhibitor | Q9HD36 | Aouacheria et al., 2001 |
BCL2A1 | Bfl1 | Bcl2a1, Bcl2l5 | inhibitor | Q16548 | Lin et al., 1993 |
BAX-like
Gene name | Protein name | Synonyms | Primary function | BCL2DB acc. | Reference |
---|---|---|---|---|---|
BAX | Bax | Bcl2l4 | promoter | Q07812 | Oltvai et al., 1993 |
BAK1 | Bak1 | Bcl2l7 | promoter | Q16611 | Chittenden et al., 1995 |
BOK | Bok | Bcl2l9, Mtd | promoter | Q9UMX3 | Inohara et al., 1998 |
BCL-WAV | Bcl-WAV | - | promoter | D2Y5Q2 | Prudent et al., 2013 |
BID-like
Gene name | Protein name | Synonyms | Primary function | BCL2DB acc. | Reference |
---|---|---|---|---|---|
BID | Bid | Bid | promoter | P55957 | Wang et al., 1996 |
BCL2L12 | Bcl2l12 | Bpr | promoter | Q9HB09 | Scorilas et al., 2001 |
BCL2L13 | Bcl2l13 | Bcl-rambo, Mil1 | promoter | Q9BXK5 | Kataoka et al., 2001 |
BCL2L14 | Bcl2l14 | Bcl-G | promoter | Q9BZR8 | Guo et al., 2001 |
BCL2L15 | Bcl2l15 | Bfk | promoter | Q5TBC7 | Coultas et al., 2003 |
Other cellular homologs
Gene name | Protein name | Synonyms | Primary function | BCL2DB acc. | Reference |
---|---|---|---|---|---|
ced-9 | CED-9 | - | inhibitor | P41958 | Hengartner et al., 1994 |
Buffy | BUFFY | Drob-2, dBorg-2 | inhibitor | Q8T8Y5 | Brachmann et al., 2000 |
debcl | Debcl | Drob-1, dBorg-1, dBok | promoter | Q9V9C8 | Colussi et al., 2000 |
bhp2 | BHP2 | - | ??? | Q967D2 | Wiens et al., 2001 |