BH3-only

In humans, the BH3-only subgroup consists of seven well-characterized proteins (for BID see Nomenclature). Contrary to cellular BCL-2 homologous proteins, these classical BH3-only proteins are evolutionarily unrelated to each other (i.e., they have not arisen from a common ancestor by gene duplication). In invertebrate species, there is only one well-characterized BH3-only protein: EGL-1 (encoded by the C. elegans genome).

Gene name	Protein name	Synonyms	Primary function	BCL2DB acc.	Reference
BCL2L11	Bim	Bcl2l11, Bod	promoter	O43521	O'Connor et al., 1998
BBC3	Puma	Bbc3	promoter	Q9BXH1	Han et al., 2001
BAD	Bad	Bcl2l8, Bbc2	promoter	Q92934	Yang et al., 1995
BIK	Bik	Nbk, Blk	promoter	Q13323	Boyd et al., 1995
BMF	Bmf	-	promoter	Q96LC9	Puthalakath et al., 2001
egl-1	Egl-1	-	promoter	O61667	Conradt et al., 1998
HRK	Hrk	Dp5	promoter	O00198	Inohara et al., 1997
PMAIP1	Noxa	Apr, Pmaip1	promoter	Q13794	Oda et al., 2000