Welcome to the BCL2DB home page !
The BCL-2 Database, BCL2DB, is a collection of sequence, structural and functional information about BCL-2 homologous and BH3-containing proteins, which are among the most studied in cell biology.
Research over the years has expanded the list of proteins structurally or functionally linked to BCL-2 (B-cell lymphoma-2), the product of a proto-oncogene identified almost thirty years ago. Discovery of the BCL-2 gene defined a new class of proto-oncogenes that block cell death without enhancing cell proliferation. Today, this protein group is formed by a family of BCL-2 homologs (which have phylogenetic relationships), and by a collection of evolutionarily and structurally unrelated proteins characterized by the presence of a region of local sequence similarity with BCL-2, termed the BH3 motif. BCL-2 homologous proteins share a similar α-helical bundle fold (the BCL-2 domain), have up to four different BH motifs (BH1-BH4), and can be either anti-apoptotic (e.g., BCL-2 and BCL-xL) or pro-apoptotic (e.g., BAX, BAK and BID). All the other (non-BCL-2 homologous) proteins possessing a functional BH3 motif are pro-apoptotic (such as the BH3-only member BIM or the BH3 motif-containing protein Atg12) (see nomenclature).
The current BCL2DB release is 52.0 with 5796 entries and was last updated on 2024-04-06 (see news).
The BCL2DB service has been accessed 77981 times by 16528 unique users since 2013 (see statistics).
If you use BCL2DB in your work, please cite Rech de Laval V. et al., Database (Oxford), 2014 (see about).
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